The lowered exploratory and social behaviors, and blood hyperserotonemia observed in KI males are all core phenotypes observed in animal models of ASD (Silverman et al.
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An automated tail suspension exam system (Med Associates) was utilized to measure the duration of behavioral immobility. Mice have been suspended because of the tail with tape to your vertical aluminum bar linked to a pressure gauge.
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The context-dependent nature of SERT regulation is underscored from the lack of colocalization of SERT with focal adhesion proteins in KI synapses. This means that the association of SERT with integrin signaling complexes is not essential for the regulation with the transporter by constitutive signaling downstream on the “primed” Pro32Pro33 mutant.
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